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張俊梁

張俊梁

顧問醫師

學歷

  • 國防醫學院醫學系畢業、國防醫學院醫學科學研究所博士班畢業

經歷

  • 病理檢驗部代主任/血庫醫師、衛生署署定解剖病理專科醫師/臨床病理專科醫師、三軍總醫院病理部住院醫師/總醫師/主治醫師、國軍桃園總醫院 社區醫學部主任、國防大學/國防醫學院/銘傳大學/中原大學教授、中華民國比較病理學會第三、四、五、六、七屆理事、國軍桃園總醫院 醫療部主任

專長

  • 醫務管理、臨床組織病理及細胞學診斷、臨床病理醫學診斷、腫瘤病理學、免疫暨分子病理學診斷

近年內相關研究發表之著作

  • Chang JL* et al. Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. Int J Mol Sci. 2018 Sep 10;19 (9) (SCI).
  • Chang JL et al. Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer. Cancers (Basel). 2018 Sep 5;10 (9) (SCI).
  • Chang JL* et al. Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression. BMC Genet. 2018 Aug 8;19 (1):55 (SCI).
  • Chang JL et al. Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma. Sci Rep. Sep 19;7(1):11893, 2017 (SCI).
  • Chang JL et al. Expression of neuroendocrine factor VGF in lung cancer cells confers resistance to EGFR kinase inhibitors and triggers epithelial-to-mesenchymal transition. Cancer Res. Apr 5. pii: canres.3168.2016, 2017 (SCI).
  • Chang JL et al*. Quercetin simultaneously induces G0 /G1 -phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells. Environ Toxicol. 2017 Jul;32(7):1857-1868, Mar 2, 2017 (SCI).
  • Chang JL et al. A targetable B-EGF–CITED4 axis controls oncogenesis in lung cancer. Oncogene 1–11, 2017, 2017 (SCI).
  • Chang JL et al. Wen YC, Lin YW, Cheng CW, Lai GM, Hsiao M, Lee LM.: Corrigendum: Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress. Sci Rep. Feb 22;7:42453, 2017. (SCI).
  • Chang JL et al. A New Form of Artificial Skin to Promote Permanent Wound Coverage: A Preliminary Report. Ann Plast Surg. Mar;78(3 Suppl 2):S148-S152, 2017 (SCI).
  • Chang JL et al*. Wen-Cheng Tsai and Jiun-Han Chen. Contribution of Outer Membrane Porin (Omp) K36 to Klebsiella pneumoniae induced Liver Abscess. Int J Clin Med Microbiol , 1: 112, 2016 (non-SCI).
  • Chang JL et al. Chung CH, Kao YR, Chang IS, Wu CW. Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity. Cancer Res. Dec 1;76(23):7036-7048, 2016 (SCI).

論文發表

  • Chang et al.Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth. PloS one 2016; 11 (4): e0153350 (SCI).
  • Chang JL et al.Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft. Archives of Toxicology 2015; 89 (7): 1103-17 (SCI).
  • Chang JL et al.Inflammatory response in heroin addicts undergoing methadone maintenance treatment. Psychiatry Research 2015; 226 (1): 230-4 (SCI).
  • Chang JL et al.Methylation status of insulin-like growth factor-binding protein 7 concurs with the malignance of oral tongue cancer. Journal of Experimental & Clinical Cancer Research 2015; CR 34:20 (SCI).
  • Chang JL et al.Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress. Scientific Reports 2015; 5:10420 (SCI).
  • Chang JL et al. Interactions between Environmental Factors and Melatonin Receptor Type 1A Polymorphism in Relation to Oral Cancer Susceptibility and Clinicopathologic Development. PLoS One. 2015 Mar 25;10(3):e0121677. (SCI)
  • Chang et al. Inflammatory response in heroin addicts undergoing methadone maintenance treatment. Psychiatry Res. 2015 Mar 30; 226(1):230-4. (SCI)
  • Chang et al.Inhibition of peroxisome proliferator-activated receptor gamma prevents the melanogenesis in murine B16/F10 melanoma cells. Biomed Res Int. 2014;2014:695797. (SCI)
  • Chang et al.Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. Tumour Biol. 2014 Dec;35(12):11903-11. (SCI)
  • Chang et al. Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase. Photodiagnosis Photodyn Ther. 2014 Sep;11(3):331-41. (SCI)
  • *Chang JL et al. Antibody formation in pregnant women with maternal-neonatal human platelet antigen mismatch from a hospital in northern. Taiwan. Kaohsiung Journal of Medical Science. 2014 Jan; 30(1):25-8.(SCI)
  • *Chang JL et al. Circulating level of lipocalin 2 as a predictor of severity in patients with community-acquired pneumonia. Journal of Clinical Laboratory Analysis 2013; 27(4):253-60.(SCI)
  • Chang JL et al. Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentiation and causes invasive prostate cancer in mice. The American Journal of Pathology 2013; 182(3):975-91.(SCI)
  • Chang JL et al. Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development. PloS One 2013; 8(9):e72940.(SCI)
  • Chang JL et al. Adenoid cystic carcinoma of the external auditory canal.
    Journal of the Chinese Medical Association: JCMA 2012; 75(6):296-300.(SCI)
  • Chang JL et al.Attenuation of the extract from Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats. The Chinese Journal of Physiology 2012; 55(1):22-30. (SCI)
  • Chang JL et al.Bronchiolitis obliterans organizing pneumonia due to titanium nanoparticles in paint. The Annals of Thoracic Surgery 2012; 93(2):666-9.(SCI)
  • Chang JL et al.Hypoxia enhances the stemness markers of cochlear stem/progenitor cells and expands sphere formation through activation of hypoxia-inducible factor-1 alpha. Hearing Research 2011; 275(1-2):43-52.(SCI)
  • Chang JL et al. Different culture medium formulations induce variant protein expression patterns of outer membrane porins in Klebsiella pneumoniae. Journal of Chemotherapy, 2011; 23(1):9-12.(SCI)
  • Chang JL et al.Rab23 plays a role in the pathophysiology of mesangial cells–a proteomic analysis. Proteomics 2011; 11(3):380-94.(SCI)
  • Chang JL et al. Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clinical cancer research:an official journal of the American Association for Cancer Research 2010; 16(17):4363-73.(SCI)
  • Chang JL et al.Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission. American Journal of Physiology. Renal Physiology 2010; 299(1):F43-8.(SCI)
  • Chang JL et al.Extramedullary-intradural spinal metastasis of small cell lung cancer causing cauda equina syndrome. The American Journal of the Medical Sciences 2010; 339(2):192-4.(SCI)
  • Chang JL et al.Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B. American Journal of Physiology. Renal Physiology 2010; 298(1):F109-17.(SCI)
  • Chang JL et al./u> G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Research 2009; 69(15):6122-30.(SCI)
  • Chang JL et al.Intrapulmonary psammomatous melanotic schwannoma.(SCI)
    The Journal of Thoracic and Cardiovascular Surgery 2009; 137(1):e25-7.
  • Chang JL et al. Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs. Journal Biomedical Science 2009, 16:2 (SCI).
  • Chang JL et al. Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice. PLoS ONE 2007; 2:e1237 (SCI). (*These authors contributed equally to this work). (SCI)
  • Chang JL et al. Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters. Disease Markers 2007; 23(3):153-60 (SCI).
  • Chang JL et al. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Experimental Cell Research 2006;312(7):962-73 (SCI)

個人榮譽

  • 榮獲第七屆細胞及分子生物新知研討會: 徐千田博士紀念優秀論文獎佳作, 89年2月 (An reward of Seventh Symposium on Recent Advances in Cellular and Molecular Biology; Dr. Chieh-Tein Hsu’s Award Presentation, February, 2000).
  • 榮獲2004年第31屆軍醫學術研討會—國防醫學院軍醫學術大會優秀論文獎
  • 榮獲96年度國防部優秀醫護人員
更新日期：111-08-04瀏覽人次：1,073回前頁
更新日期：111-08-04瀏覽人次：1,074回前頁